The Wyss Institute for Biologically Inspired Engineering at Harvard has been awarded a $12.3 million, four-year grant from the Defense Advanced Research Projects Agency (DARPA) to develop a treatment for sepsis, a commonly fatal bloodstream infection. Sepsis is a major cause of injury and death among combat-injured soldiers in the field, as well as patients in hospital intensive care units.The proposed treatment would involve a miniaturized, dialysislike device that could rapidly clear the blood of a wide range of pathogens, much as a living human spleen does, without removing normal blood cells, proteins, fluids, or electrolytes. This novel “Spleen-on-a-Chip” would be portable, self-contained, and easily inserted into the peripheral blood vessels of a septic patient or soldier.The award, which was announced Sept. 28, is part of DARPA’s Dialysis Like Therapeutics (DLT) program, which seeks to develop ways to dramatically decrease the morbidity and mortality of sepsis. Worldwide, more than 18 million cases of sepsis are reported every year, with more than 6 million resulting in death.“We are very proud to partner with DARPA to pursue a research effort that could potentially transform how we treat patients with sepsis and save lives by quickly cleansing blood free of pathogens while simultaneously treating with antibiotics,” says Donald Ingber, Wyss Institute founding director and principal investigator on the grant. “This is a tremendous example of how the Wyss Institute works to bring together outstanding faculty members, expert technical staff, interdisciplinary resources, novel technologies, and clinical partner institutions, such as Children’s Hospital Boston, to bear on critical medical problems.”The project also includes George Church, a Wyss core faculty member and professor of genetics at Harvard Medical School; Joanna Aizenberg, a Wyss core faculty member and Amy Smith Berylson Professor of Materials Science at the Harvard School of Engineering and Applied Sciences and Susan S. and Kenneth L. Wallach Professor at the Radcliffe Institute; and Michael Super, a member of the Wyss Advanced Technology Team, as key co-investigators.Researchers plan to incorporate several of the Wyss Institute’s novel technologies in the proposed sepsis dialysis device. The sepsis therapeutic device will leverage recent Wyss Institute advances in organ-on-chip technologies in which key microstructural features of complex organs, such as the spleen, are replicated in microfluidic circuits using microfabrication techniques.Also key to the technology is the use of magnetic nano- and micro-particles coated with a human opsonin — a key component of the body’s innate immune response — that will remove pathogens from flowing human blood using magnetic forces. The opsonin is being genetically engineered to improve its already broad pathogen-binding capacity using directed evolution strategies developed at the institute.In addition, the sepsis therapeutic device will incorporate a “super” slippery surface that was developed by institute researchers as a novel material to prevent the adhesion of ice, crude oil, or even dirt. This technology, which is modeled after the slippery surfaces of carnivorous plants that trap insects sliding into the digestive juices of the plant, will be modified to prevent blood clot formation so that patients will not need to be treated with anticoagulants, such as heparin, when attached to the sepsis therapeutic device.The Wyss Institute is a division of Harvard University. Operating in collaboration with Harvard Schools, Harvard-affiliated hospitals, Boston University, and the University of Massachusetts Medical School, the Wyss Institute conducts broad interdisciplinary research into the principles that living systems use to build, control, and manufacture, and applies these insights to develop novel materials and devices in areas as diverse as architecture, medicine, robotics, manufacturing, and the environment.
Dele Alli marked his first Tottenham run-out with a goal as Brentford were overcome 2-1 in a behind-closed-doors friendly on Wednesday. The midfielder converted the second spot-kick of the match in stoppage-time, with Shaq Coulthirst having scored the first before Jermaine Udumaga pulled one back at the death. Toby Alderweireld also played his first match for Spurs since joining from Atletico Madrid, starting the match alongside fellow new boys Kevin Wimmer and Kieran Trippier. Press Association Signed from MK Dons in February, the 19-year-old was spent the remainder of last season on loan at his home-town club, helping them secure automatic promotion from League One. It meant Alli’s first appearance for Spurs only arrived on Wednesday, when his penalty helped overcome the Championship Bees 2-1 at Hotspur Way.
For all the Latest Sports News News, Cricket News News, Download News Nation Android and iOS Mobile Apps. New Delhi: That Virat Kohli is destined to be among the pantheons of all-time greats is an oft-repeated assertion but for former Australia captain Michael Clarke, the India skipper is already the “greatest ODI batsman to have ever played the game”. Kohli, the world’s no.1 Test and ODI batsman, led India through a historic tour of Australia, during which the team won the Test and ODI rubbers and drew the T20 International series. Kohli’s India was the first team ever not to lose any series Down Under and along the way, he continued to add to his rapidly-rising count of international hundreds.“To me, Virat Kohli is the greatest batsman to have ever played one-day cricket. I have no doubts after seeing what he has achieved for India,” Clarke, himself a former World Cup-winning captain, told PTI in an interview. Kohli has already scored 10,385 runs in 219 ODIs with an astounding average of 59 plus, including 39 hundreds.An unabashed Kohli fan, Clarke said that the 30-year-old Indian’s passion is unmatchable. “You have to respect Virat’s passion to win games for his country. Yes, he has aggression but no one can question his commitment, how much he has achieved. He is the greatest in ODIs,” Clarke said.Also Read | Virat Kohli’s India in Australia: Five memorable moments from historic tourWhile Kohli’s craft continues to evoke awe, his predecessor Mahendra Singh Dhoni’s current form has the cricketing world divided. Dhoni’s style of batsmanship in ODIs, no longer as aggressive as it used to be, has been a matter of concern but for Clarke, the 37-year-old former India captain should be left alone to play his game.“MS knows how to react to any given situation. He has played 300 plus ODIs so he knows how to go about his job,” Clarke said.But would Dhoni have been as effective as he was in the third ODI against Australia if the target would have been 330 instead of 230?“I think he would have played differently. It was 230 and he had a particular strategy and it would have been different if the target would have been bigger,” he said.“Look at his approach in the second game in Adelaide and the third game in Melbourne. It was different,” Clarke said.Asked what should be Dhoni’s batting position in the World Cup, Clarke said, “Any position 4, 5 or 6. He is good enough to bat at any position and I believe Virat will use him accordingly.”Clarke, however, made it clear that the currently suspended Hardik Pandya would play an important role for India going into the World Cup in England. Pandya faces, as of now, an uncertain future owing to his much-condemned sexist remarks on a TV show.“A talented player like Hardik is very necessary for the balance of the side. He can win games alone with his batting and I am confident he will be in that World Cup squad,” Clarke sounded confident. While he didn’t speak about the Pandya-KL Rahul controversy but Clarke looked at the bigger picture about professional sportspersons being role models. He stressed on the aspect of “respect”.Asked if a lot of money is making youngsters go haywire in their conduct, Clarke gave his insight. “How much money you have earned is irrelevant because most important thing is to earn and give respect. I think it all starts with how you have been brought up.Also Read | Let Hardik Pandya, KL Rahul play while inquiry is on: BCCI president CK Khanna“Respecting every individual is very important. It starts with respecting elders regardless of profession,” Clarke, who has been a chip of the old bloc when it comes to traditions, said. But former batting mainstay also spoke about the need to not make one “mistake” the focus of somebody’s career.“Professional sportspersons are role models, recognized and they have a responsibility. Having said that, everyone makes mistakes and one needs to move on and learn from them,” said Clarke, who played 115 Tests and 245 ODIs for Australia.Asked if India are favourites to win the World Cup, Clarke said, “Certainly one of the favourites with the kind of bowling talent India have at the moment. The batting was always strong and they also have wonderful young spinners. What has impressed Clarke is the fact that India doesn’t have any “apparent weakness in the bowling department”.“Jasprit Bumrah is a skillful bowler who is improving every day. He continues to get better with his seam, swing, and pace. He is the best death bowler in ODI cricket at the moment,” said Clarke.However, the cricket analyst in him also feels that England will be a very difficult team to beat at home. “England is a very good ODI side and will be hard to beat at home. Also, I would like Australia to be in the mix. Australia will get better when the frontline pacers including Nathan Coulter Nile come back,” explained Clarke.Talking about Australian cricket, Clarke is hopeful that things will change for the better very soon if there is good leadership (not captaincy). “There is plenty of talent in Australian cricket. We have good young players playing Sheffield Shield. They still believe Test cricket is the pinnacle,” he said. But he offered a word of caution too. A lot of hard work is needed and good leadership, which can select the right guys, back them and give them time to perform,” he said.