Tag: 浙江龙凤

The String Cheese Incident Welcomes Scott Sharrard At Scorching Summer Tour Closer

first_imgAfter a fun first night at the Kings Theatre, the String Cheese Incident returned to Brooklyn last night to complete their two-night run and their Summer tour to a close. The show was filled with thrilling moments, excellent jams, spot-on covers, and a high octane guest spot from Gregg Allman Band’s Scott Sharrard.Coming out of the gate hot, the band opened with a thumping, extended version of “Valley Of The Jig” that really got the crowd moving. The soulful and funky “Black And White” came next, and the band took that song out for a walk before segueing into a fun, Latin-tinged “Yo Se”. After a quick version of “Farther”, the band played “Sweet Spot”, a track from the band’s new SCI Sound Lab project. SCI kept the newer songs going with a fun take on the Kyle Hollingsworth tune “Stop Drop Roll” before finishing up set one with a huge, locked in version of their classic “Round The Wheel”.After a short break, SCI returned to the stage and immediately picked up where they left off. “Desert Dawn” was the perfect set two opener. After a spirited run through the song’s form, the band performed easily the jam of the night, moving as a unit through several unique, progressive rock-like sections before bringing the song to its natural end. The impressive improv section was a true highlight in a show filled with them.After the raging set two opener, the band returned to their Sound Lab to perform another new track, “Get Tight”. After a short-but-sweet version of the new song, the band picked things back up with a funky version of “Rain” that gave the band another opportunity to stretch out their improv muscles, with Michael Kang coming in at the perfect time to bring the jam to its climax.Rhythm guitarist / singer Billy Nershi then stepped up to the microphone to introduce a special guest, none other than Scott Sharrard. Sharrard played the entire Allmans Family Incident with the band at The Peach Festival on Friday, serving as band leader as the band worked through a set of Allman Brothers classics. The band seemed to be loving the Allman Brothers musical vibe, and kept the party going with incredible versions of “Hot’Lanta” and “Southbound” that simply had the audience going bananas. Sharrard was particularly impressive, trading lead solos with Michael Kang in true tension-release fashion, creating an enormous amount of energy in the room. Anyone who was at The Peach on Friday was gifted with some bonus Allmans material, and anyone who missed The Peach was absolutely blessed to catch some of the magic from that performance. Sharrard and SCI also managed to slip in a version of “On The Road” in between the two covers, and overall created a huge, non-stop segment of musical magic.Watch “Hot ‘Lanta” below, courtesy of Gabe Sokker.Sharrard left the stage to raucous applause, and the band kicked into the evening’s final segment. Starting with “Way Back Home”, the band moved quickly into “Whiskey Before Breakfast” before landing on an out-of-left-field, set-closing cover of Led Zeppelin‘s epic rocker “Kashmir” that left the crowd begging for more.The band took a short break before delivering a three-song encore to finish their summer tour. Opening with “Honky Tonk Heroes”, the band then turned in a quick version of “Hobo Song” before creating one more opportunity to rage with their fans, bringing things to a close with a huge version of “Rosie” that had the crowd dancing all the way out of venue and into the streets of Brooklyn.After a great summer that saw the String Cheese Incident bring their carnival-esque live show across the country, the band capped off their summer with an excellent show that found the band truly locked in and in command of their collective sound. The fun covers, spirited jamming, and all-around positive vibes all add up to a band that’s currently at the top of its game.The String Cheese Incident will now take a few months off before they play three nights at Suwanee Hulaween this October.The String Cheese Incident | Kings Theatre | Brooklyn, NY | 8/15/2016Set 1: Valley of the Jig, Black and White > Yo Se, Farther, Sweet Spot, Stop Drop Roll, Round the WheelSet 2: Desert Dawn, Get Tight, Rain, Hot ‘Lanta[1], On the Road[1] > Southbound[1], Way Back Home > Whiskey Before Breakfast > KashmirEncore: Honky Tonk Heroes, Hobo Song, Rosie[1] Feat. Scott Sharrard on guitarlast_img read more

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Joe Russo’s Almost Dead Welcomes Nicole Atkins For Their Ryman Auditorium Debut [Setlist/Videos]

first_imgJoe Russo’s Almost Dead played at the famed Ryman Auditorium last night in Nashville, Tennessee. The Grateful Dead tribute band, continuously reinventing old tunes into new, is on the road this week, hitting Charleston’s Music Farm tonight, and two Florida appearances this weekend with the Sunshine Blues Music Festival in St. Petersburg and Boca Raton.The southern run started off strong last night, with appearances from Nicole Atkins throughout both sets. The vocalist sat in on “The Music Never Stopped” and “Dancin’ In The Streets” during set one, and returned for “The Stranger (Two Souls In Communion)” during the second set.A few clips have surfaced on the Internet with from these YouTube and Instagram users, including this snippet of “Terrapin” and more! Setlist: Joe Russo’s Almost Dead | Ryman Auditorium | Nashville, TN | 1/12/17Set 1 (7:51PM – 9:08PM)Truckin’ (SM) ->Tennessee Jed @ (TH) ->The Music Never Stopped (SM & NA)>Dancing In The Streets (SM & NA) ->Brown Eyed Women (TH)Set 2 (9:47PM – 11:30PM)Help On The Way (TH) ->Slipknot! $ ->Throwing Stones % (SM) ->Dark Star Jam ^ ->Throwing Stones Reprise (SM)The Stranger (Two Souls) (NA) >Let It Grow & (SM) ->He’s Gone (All) >Terrapin Station * (TH)ENC: GDTRFB (All with NA) ->WBYGN (Instrumental ending)@ – With unknown tease MB# – With a “Don’t Stop ’Til You Get Enough” (Michael Jackson) Jam (Band)$ – TH broke a string% – With a Dancin Tease (TH)^ – With a GDTRFB Tease (TH)& – With a “Norwegian Wood” (The Beatles) Tease (SM) & a “Kashmir” Jam (SM & Band)* – With Ruben & Cherise Teases (MB then Band) an “Eleanor Rigby” (The Beatles) Jam (TH & Band)[photo via @doranseladams on Instagram]last_img read more

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Courtney Love Reveals Kurt Cobain Musical ‘Very Likely’

first_img View Comments Nirvana formed in 1987 and went on to establish itself as one of the most famous grunge bands in the world, releasing a number of successful songs like “Smells Like Teen Spirit,” “Heart-Shaped Box,” “About A Girl,” “Come As You Are” and “Lithium.” Love has been embroiled in several legal battles with the surviving members of the band over song rights. Why did Love change her tune? She revealed that she had been “swarmed by tons of Nirvana fanmail and social media posts pushing for a musical to become a reality.” The key to the production getting off the ground? Love said that “there would have to be a story, and a great story, one that hasn’t been told before.”center_img Broadway might be smelling like teen spirit! The Kurt Cobain bio-musical, which was reported to be in the works before the idea was quickly squashed by the late musician’s wife Courtney Love, is back on. Love spoke with NME as part of the magazine’s tribute to the Nirvana frontman and said that if she could get the right people involved “then a Broadway musical is very likely to happen.”last_img read more

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Scientists pinpoint TIM3 protein as next potential target for immunotherapy treatments

first_imgOct 31 2018Following the 2018 Nobel Prize for Medicine, global attention is now more than ever turned toward the promise of immunotherapy in oncology. An international team’s work has shed new light on a molecule called TIM-3 that might play a key role in the regulation of the immune response. Scientists and physicians from the Research Institute of the McGill University Health Centre (RI-MUHC), the Montreal Children’s Hospital of the MUHC (MCH-MUHC), and McGill University in collaboration with French teams from AP-HP, Inserm, Université Paris-Descartes and the Imagine Institute at the Necker-Enfants Malades Hospital, have singled out this protein as the next potential target for immunotherapy treatments in patients with cancer and other diseases.These results are being published in the journal Nature Genetics on Monday, October 29.Researchers found that when the TIM-3 protein is suppressed or inactive, the immune system becomes completely “unleashed” and T cells are uncontrollably over-activated, resulting in a rare form of lymphoma (a form of cancer that starts in the lymphocytes) called subcutaneous panniculitis T lymphoma (LTSCP).The team of researchers has identified two founder mutations at the origin of this syndrome, which act directly on the TIM-3 protein, preventing it from expressing itself on the surface of the lymphocytes and attacking the cancer cells. They also found that this form of lymphoma associated with over-activation of the immune response was more widespread than they first thought. Both mutations have been found in individuals of East Asian, Australian, and Polynesian origin as well as in patients of European origin.This work was based on findings from the teams at the RI-MUHC and the MCH-MUHC, showing the same rare form of lymphoma in brother and sister. After sequencing their genomes, the researchers discovered that both patients carried the same mutation on a gene called HAVCR2 that codes for TIM-3 and that it was transmitted by their parents.In discussions with colleagues in Australia and France, the team realized they too had similar cases of patients with the same mutation (Tyr82Cys) who seemed to be mostly of East Asian or Polynesian descent. Another mutation (Ile97Met), on the same gene, was identified in patients of European origin. A functional study of these mutations, conducted in Paris, confirms their responsibility in this new genetic disease. In all, 17 pediatric and adult cases were the subject of this scientific publication.”The discovery of this mutation has shed light on a previously undescribed mechanism that allowed us to explain both the clinical presentation and the very particular evolution of these lymphomas under treatment,” explains Dr. David Michonneau from the hematology-transplant service in the Saint-Louis AP-HP hospital.Related StoriesLiving a healthy lifestyle may help offset genetic risk of dementiaGene modulation goes wireless hacking the “boss gene”Fungal infection study identifies specific genetic vulnerability among Hmong peopleAccording to Dr. Geneviève de Saint Basile from the laboratory “Molecular basis of immune homeostasis abnormalities” Inserm at the Imagine Institute and the center for the study of immunodeficiencies at Necker-Children’s Hospital AP-HP, “The results of this collaboration demonstrate the regulatory role of the TIM-3 molecule in humans and they also provide strong arguments for reconsidering this entity as an inflammatory rather than a malignant pathology, and for promoting the use of immunosuppressive drugs in its treatment.””For these patients with this rare form of lymphoma, our results reinforce the use of immunosuppressive therapies that will provide much better results and fewer side effects than cytotoxic chemotherapy,” says Dr. Nada Jabado, who is a clinician-scientist from the Child Health and Human Development Program at the RI-MUHC and a professor of Pediatrics and Human Genetics at McGill University in Montreal.Researchers are now trying to see if patients with autoimmune diseases such as lupus – a disease where the immune system turns against the body itself – may have some TIM-3 dysfunction. There would also be promising avenues for the treatment and understanding of cancers, infectious diseases such as HIV or even malaria as well as multiple sclerosis. Source:https://muhc.ca/newsroom/news/scientific-breakthrough-promising-new-target-immunotherapylast_img read more

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Magnesium may play important role in optimizing vitamin D levels study shows

Reviewed by Kate Anderton, B.Sc. (Editor)Dec 14 2018A randomized trial by Vanderbilt-Ingram Cancer Center researchers indicates that magnesium optimizes vitamin D status, raising it in people with deficient levels and lowering it in people with high levels.The study reported in the December issue of The American Journal of Clinical Nutrition is important because of controversial findings from ongoing research into the association of vitamin D levels with colorectal cancer and other diseases, including a recent report from the VITAL trial. It gave confirmation to a prior observational study in 2013 by the researchers that linked low magnesium levels with low vitamin D levels.The trial also revealed something new — that magnesium had a regulating effect in people with high vitamin D levels. The research provides the first evidence that magnesium may play an important role in optimizing vitamin D levels and preventing conditions related to vitamin D levels.Qi Dai, MD, PhD, Ingram Professor of Cancer Research, the study’s lead author, described the ideal level as being in the middle range of a U-shape because vitamin D at this level has been linked to the lowest risk of cardiovascular disease in previous observational studies.However, vitamin D was not related to cardiovascular disease in the recent VITAL trial. He and Martha Shrubsole, PhD, research professor of Medicine, Division of Epidemiology, are investigating the role that magnesium may play with cancer as part of the Personalized Prevention of Colorectal Cancer Trial.”There’s a lot of information being debated about the relationship between vitamin D and colorectal cancer risk that is based upon observational studies versus clinical trials,” Shrubsole said. “The information is mixed thus far.”Related StoriesVitamin D supplement does not prevent type 2 diabetes in adults at high risk, study findsWinter prevents the Swiss population from producing daily doses of vitamin DLow vitamin D associated with potentially harmful vaginal bacteria in pregnant black womenThey became interested in a role for magnesium because people synthesize vitamin D differently with levels of the vitamin in some individuals not rising even after being given high dosage supplements.”Magnesium deficiency shuts down the vitamin D synthesis and metabolism pathway,” Dai said.The randomized study involved 250 people considered at risk for developing colorectal cancer because of either risk factors or having a precancerous polyp removed. Doses of magnesium and placebo were customized based on baseline dietary intake.”Vitamin D insufficiency is something that has been recognized as a potential health problem on a fairly large scale in the U.S.,” Shrubsole said. “A lot of people have received recommendations from their health care providers to take vitamin D supplements to increase their levels based upon their blood tests. In addition to vitamin D, however, magnesium deficiency is an under-recognized issue. Up to 80 percent of people do not consume enough magnesium in a day to meet the recommended dietary allowance (RDA) based on those national estimates.”Shrubsole stressed that the magnesium levels in the trial were in line with RDA guidelines, and she recommended dietary changes as the best method for increasing intake. Foods with high levels of magnesium include dark leafy greens, beans, whole grains, dark chocolate, fatty fish such as salmon, nuts, and avocados. Source:http://news.vumc.org/2018/12/14/study-shows-magnesium-optimizes-vitamin-d-status/ read more

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Researchers investigate how marijuana and tobacco couse affects quit attempts by smokers

first_imgReviewed by James Ives, M.Psych. (Editor)Feb 23 2019Tobacco isn’t the only thing being smoked in the Deep South, and for many, it’s only half of their habit.Marijuana, long thought to be a gateway drug to harder substances, turns out to be popular among cigarette smokers, with rates of co-use of the two substances increasing among adults from 2003-2012. Researchers don’t yet know how much of a problem that could pose for people trying to quit tobacco.As more states move to legalize medicinal marijuana and some to decriminalize recreational use, a better understanding is needed of how co-use of marijuana affects quit attempts by smokers.To learn more, a team of addiction investigators at the Medical University of South Carolina (MUSC) led by Erin A. McClure, Ph.D., assistant professor in the Department of Psychiatry and Behavioral Sciences, conducted an online survey of those who had used both marijuana and tobacco within a 30-day period about their smoking habits. Their results were published online on November 27, 2018 in Addictive Behaviors.”We focused on marijuana and tobacco because of the high prevalence of their co-use,” says Saima Akbar, first author on the article. “We don’t fully understand how these substances interact and what the implications are for treatment.”The MUSC team found that more participants used marijuana and tobacco sequentially than simultaneously. For example, more participants used a tobacco cigarette as a “chaser” to marijuana than smoked joints mixing both marijuana and tobacco, known as spiffs.The study also found that the degree to which marijuana and tobacco use were interrelated differed greatly by user. However, 26 percent of users reported they had smoked most of their cigarettes around the time they were using marijuana or were high. They were more likely to have a greater tobacco dependence and to smoke more cigarettes per day.”So, if somebody’s trying to quit smoking cigarettes, but they always use marijuana and tobacco together, it’s probably going to be much, much harder for them if they are still using marijuana than for somebody who uses both, but their use is not related in any way,” says McClure.The finding also raises the question of whether smoking tobacco after marijuana use enhances its subjective effects. More than 50 percent of those surveyed reported using tobacco cigarettes as a chaser. However, another 35 percent reported not doing so. It is possible that co-users of marijuana and tobacco who feel a more intense high because of the tobacco use would be more likely to use them closer together. They could have a harder time quitting smoking than those who did not feel such an enhanced high. This possibility requires further study.Related StoriesNicotine delivery devices are harmful and do not help smokers to quitStudy: Tobacco and alcohol usage are common in British reality television showsCo-use of cannabis and tobacco associated with worse functioning, problematic behaviorsWhat is clear from the researchers’ findings is that everyone’s habit is a little different, and cessation programs will need to be personalized if they are to be effective.McClure hopes to focus on tobacco cessation as she continues her research but also identify the people who will likely struggle with quitting due to their marijuana use. She then plans to further tailor treatment to these individuals to improve the likelihood that their smoking cessation efforts will be successful.”We need to tailor a treatment strategy for each individual rather than doing this one-size-fits-all approach that doesn’t always work very well,” says McClure.For instance, in an age of medical marijuana and increasing legalization, not all users wanting to quit tobacco will want to discontinue marijuana as well. For some, with a lesser degree of interrelatedness between their use of the two substances, this may be possible. But for those with a higher degree of interrelatedness, dual cessation strategies could be needed.McClure is pursuing funds for a prospective clinical trial that would further explore how marijuana co-use affects tobacco cessation and compare quit attempts and cessation rates in co-users and tobacco-only users.”That trial would help us identify the people who are going to have more difficulty with quitting smoking cigarettes because of their marijuana use, and how we can tailor treatment for them,” says McClure. “It would also help clarify how we can tailor treatment for those not interested in quitting marijuana so that they still have the best chances of stopping cigarette smoking.”​ Source:https://web.musc.edu/about/news-center/2019/02/22/a-joint-problem-investigating-marijuana-and-tobacco-co-uselast_img read more

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How were designing musical instruments with the help of disabled musicians and

first_img Citation: How we’re designing musical instruments with the help of disabled musicians and VR (2019, January 16) retrieved 17 July 2019 from https://phys.org/news/2019-01-musical-instruments-disabled-musicians-vr.html Most new digital technologies tend to be designed with an able-bodied user in mind. The first desktop computers required fine motor skills to navigate software menus using a mouse, and mobile phones need users to press buttons, swipe screens, and so on. To use such technology a person needs to be fairly dexterous. Explore further This article is republished from The Conversation under a Creative Commons license. Read the original article. For our clarinettist we focused on the VIVE controllers, as they are more tactile than visual. They can also track physical positions in a space, which meant the clarinettist was able to position sounds in the 3-D Sonic LAB by having the VIVE controller strapped to his instrument.Inclusive thinking and designThese bespoke VR instrument designs featured in a showcase concert in November 2018, where disabled musicians performed alongside musicians from the Hard Rain Soloist Ensemble.The audience was positioned in a circle closely surrounding the musicians in order to enhance the immersive experience of the performance space.The disability equipment market worldwide is estimated to increase to more than US$8 billion by 2020, and sales of disabled equipment in the UK have increased over 93% over the last ten years. All technologies, including VR, can be inclusive if the perspective of disabled people is part of their design. Our approach reveals how new technologies can be developed, that actively engage disabled musicians in music making and demonstrate a commitment to quality of life for disabled musicians. We will continue to design instruments that can be used in VR, but we will now focus on using more affordable systems, with a view to creating a virtual reality ensemble of disabled and able-bodied musicians. How to dance to a synthetic band Virtual Reality technology opens up new experiences and possibilities in music for people with disabilities. Credit: Performance Without Barriers, Author provided The instrument was developed with able-bodied musicians in mind, so we designed it to take into account different types of mobilities. This led to one of our musicians with cerebral palsy playing a new VR instrument that was specifically designed to take into account her expressive upper body movements. It did not require her to use fine motor precision in her arms or fingers, which she does not possess. Virtual Reality technology opens up new experiences and possibilities in music for people with disabilities. Credit: Performance Without Barriers, Author provided Provided by The Conversation VR headsets are necessarily about what you see. However, we found that the tactile feedback from the hand-held controllers – through which a user accesses a menu and press commands to reach content – allowed this particular musician to play the instrument by feeling and hearing it, rather than seeing it through the headset. Not having to rely on the headset also meant she could maintain visual contact with other musicians during the performance.Another example of our collaborative VR design was working with a blind performer. Key to this musician were his virtuosic skills on the clarinet. The idea was to build on his expertise and adapt and enhance his musical performance skills using VR technologies.VR experiences are so concentrated on the visual experience that often they disregard the inherently immersive nature of sound, but it’s all around us, a proper 360° experience. Clearly, a visual headset was not relevant or helpful to this blind musician. We needed to focus on how we could use the other immersive qualities of a space for a music performance.Our team is based at the Sonic LAB in Queen’s, an immersive and fully customisable 3-D sound space – often referred to as the iMAX for the ears – we decided to adapt the VIVE technology to this existing context. In our Performance without Barriers research group, we design digital musical interfaces with disabled musicians in mind. This work engages disabled performers from the start of a new technology and looks at the specific abilities they have. In this way, technologies develop in tandem with them, taking into account their mobility, needs and creative interests.Current VR technology is designed for the able bodied, but more importantly it often allows only for passive interactions – listening to music performances, such as Elton John’s 360 concert, for example, or “riding” a rollercoaster. We were more interested in how disabled musicians can use VR technologies in an active and performative way.Working togetherOur research team consists of a diverse group, including electronic engineers, computer scientists, sonic arts researchers, immersive content designers, a soloist ensemble and a local group that helps disabled musicians perform and compose their own music independently. Together with these musicians, we teamed up with a US software developer, who was designing a VR musical instrument called the “Infinite Instrument”, running on a 360° VR headset called HTC VIVE. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

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