Reyes Aragon has been wanted for drug trafficking since 2010, when Nicaraguan police issued an arrest warrant for him. The OIJ had been investigating the activities of Reyes Aragon and Los Tarzanes since 2012, according to OIJ Director Francisco Segura Montero. Los Tarzanes, which is allegedly is run by Reyes Aragon and his six brothers, is suspected of smuggling cocaine from Colombia and marijuana from Jamaica into Costa Rica. Authorities believe Los Tarzanes operatives store the drugs in Limon for later shipment by boat or truck to Honduras and Mexico, or for sale in Costa Rica’s domestic illicit drug market. Los Tarzanes In addition to the arrests of the suspected members of Los Tarzanes, Costa Rica police and security forces have scored a number of successes against transnational criminal organizations engaged in the drug trade. For example, on June 10 and 11, 2014, the Costa Rica Coast Guard seized more than 4 tons of cocaine found on Costa Rican fishing boats off the Pacific Coast. The seizure was reportedly the largest in the country’s history. Costa Rican drug seizures have more than doubled since 2011. Costa Rica security forces have dismantled more than a dozen international drug trafficking operations since 2006, according to published reports. The capture of Reyes Aragon and the increase in drug seizures may indicate that Costa Rican security forces are improving their effectiveness in fighting drug trafficking, said Armando Rodríguez Luna, a security analyst at the National Autonomous University of Mexico (UNAM). Costa Rican security forces have improved their effectiveness in fighting Los Tarzanes and other organized crime groups “because they have improved their ability to protect the country’s border in the fight against drug trafficking, and they have continued to collaborate and exchange information with other governments in joint border operations,” according to Rodríguez Luna. Julieta Pelcastre contributed to this article. Costa Rican authorities have arrested the alleged leader of a Nicaraguan drug trafficking group known as Los Tarzanes. Agents of Costa Rica’s Judicial Investigation Body (OIJ) arrested Agustin Reyes Aragon, 40, on June 12. They arrested Reyes Aragon during a series of raids in the Caribbean coastal province of Limon. Security forces also detained three other suspects: a Nicaraguan man, a Honduran man, and a female whose nationality was not immediately determined. OIJ agents confiscated two AK-47 assault rifles, a vehicle and currency in the amount of $14,000 (USD) and one million colones during the raids. Wanted in Nicaragua Los Tarzanes was founded in the mid-1990s as part of a drug trafficking network operated by the now defunct Norte del Valle Cartel in Colombia, Nicaraguan police have said. Operating primarily as transporters, Los Tarzanes operatives use go-fast boats and vehicles to move shipments of Colombian cocaine and precursor chemicals for methamphetamine production north for eventual sale to Mexican transnational criminal organizations such as the Gulf Cartel (CDG). Los Tarzanes was originally based along Nicaragua’s southern border. In recent years, as Nicaraguan security forces have increased patrols in that region, the drug trafficking group has increased its operations on the Costa Rican border. Costa Rican security successes By Dialogo July 02, 2014
Cambridge, Ma. — A mysterious cigar-shaped object spotted tumbling through our solar system last year may have been an alien spacecraft sent to investigate Earth, astronomers from Harvard University have suggested.The object, nicknamed ‘Oumuamua, meaning “a messenger that reaches out from the distant past” in Hawaiian, was first discovered in October 2017 by the Pan-STARRS 1 telescope in Hawaii.Since its discovery, scientists have been at odds to explain its unusual features and precise origins, with researchers first calling it a comet and then an asteroid, before finally deeming it the first of its kind: a new class of “interstellar objects.”Now, a new paper by researchers at the Harvard Smithsonian Center for Astrophysics raises the possibility that the elongated dark-red object, which is 10 times as long as it is wide and traveling at speeds of 196,000 mph, might have an “artificial origin.”“‘Oumuamua may be a fully operational probe sent intentionally to Earth vicinity by an alien civilization,” they wrote in the paper, which has been submitted to the Astrophysical Journal Letters.The theory is based on the object’s “excess acceleration,” or its unexpected boost in speed as it traveled through and ultimately out of our solar system in January 2018.“Considering an artificial origin, one possibility is that ‘Oumuamua is a light sail, floating in interstellar space as a debris from an advanced technological equipment,” wrote the paper’s authors, suggesting that the object could be propelled by solar radiation.The paper, written by Abraham Loeb, professor and chair of astronomy, and Shmuel Bialy, a postdoctoral scholar, at the Harvard Smithsonian Center for Astrophysics, points out that comparable light-sails already exist on earth.“Light-sails with similar dimensions have been designed and constructed by our own civilization, including the IKAROS project and the Starshot Initiative. The light-sail technology might be abundantly used for transportation of cargos between planets or between stars.”In the paper, the pair theorize that the object’s high speed and its unusual trajectory could be the result of it no longer being operational.“This would account for the various anomalies of ‘Oumuamua, such as the unusual geometry inferred from its light-curve, its low thermal emission, suggesting high reflectivity, and its deviation from a Keplerian orbit without any sign of a cometary tail or spin-up torques.”‘Oumuamua is the first object ever seen in our solar system that is known to have originated elsewhere.At first, astronomers thought the rapidly moving faint light was a regular comet or an asteroid that had originated in our solar system.Comets, in particular, are known to speed-up due to a process known as “outgassing,” in which the sun heats up the surface of the icy comet, releasing melted gas. But ‘Oumuamua didn’t have a “coma,” the atmosphere and dust that surrounds comets as they melt.Multiple telescopes focused on the object for three nights to determine what it was before it moved out of sight.“We are fortunate that our sky survey telescope was looking in the right place at the right time to capture this historic moment,” NASA Planetary Defense Officer Lindley Johnson said in a statement last year.“This serendipitous discovery is bonus science enabled by NASA’s efforts to find, track and characterize near-Earth objects that could potentially pose a threat to our planet.” CNN Wire Report
New look ARC revamps executive leadership team February 18, 2020 StumbleUpon Related Articles ARC continues financial support for greyhound trainers during COVID-19 shutdown April 15, 2020 Share Share ITV secures three-year British racing broadcast deal August 5, 2020 Submit The Arena Racing Company (ARC) has revealed a multi-million pound development scheme for Newcastle Racecourse and High Gosforth Park, following on from the success in similar previous work undertaken.Planning to submit its plans for the next stages of its development to Newcastle City Council in Autumn this year, it is hoped the proposals will boost the international prestige of the racecourse, in addition to creating a plethora of new jobs and driving a significant uplift of visitor numbers through the city. Improvement detailed for the racecourse estate includes an approximate 3,500m2 events centre, alongside significant refurbishment of the public and hospitality areas, as well as the racing staff accommodation. In its media statement ARC also outlined its plans for High Gosforth Park, which includes the development of “high quality” residential accommodation, and refurbishment to the listed Brandling House and its associated public space.David Williamson, Executive Director of Newcastle Racecourse, said “Our plans will complete the transformation of Newcastle Racecourse into a world class sporting venue. The development of the racecourse, and the wider High Gosforth Park Estate, will provide a significant boost to Newcastle’s local economy and help create a number of jobs.“These plans will completely transform the customer experience here at Newcastle, with brand new facilities for racegoers including bars, restaurants and hospitality suites, alongside significant upgrades for owners and trainers as well as the accommodation for racing staff. “We very much look forward to hearing people’s views on the plans, and welcome feedback at the exhibition on 31 August. We look forward to introducing the public to our plans and hearing their views.” A public consultation has been launched on the plans, with local residents invited to submit their views. Newcastle Racecourse will host a public exhibition and drop-in session before racing on 31 August between 12:00 and 16:00.
elyssa pallai 8 Best WordPress Hosting Solutions on the Market Related Posts Top Reasons to Go With Managed WordPress Hosting In the spirit of all things being not equal, ReadWriteWeb is offering a deep discount to independents, freelancers and individual consultants for the ReadWriteWeb Real-Time Web Summit, June 11 in New York City. Simply email [email protected] to take advantage of the discount. Richard MacManus is packing his bags in New Zealand as we speak in anticipation of meeting you in New York! As we plan our week in New York for the conference and Internet Week, we’re looking at the attributes of the real-time Web that independents – including entrepreneurs, consultants and freelancers – should know about. Here are five use cases for the real-time Web that demonstrate its relevance for independents like yourself. 1. Real-time technologies change the user experience As the Web goes real-time, the World Wide Wait just isn’t going to cut it. Users will come to expect everything right now, and served up via instant notification. It will be interesting to see how this impacts users’ desires to actually visit websites. Or will we become so used to instant transfer of knowledge and notifications that it will change the very nature of how we use the Web? 2. Real-time technology enhances collaboration and crowdsourcing Crowdsourcing will become possible on a mass scale. Instead of you and four other collaborators to get the job done, try thousands. Imagine Mechanical Turk on steroids and think of all the work you can get done, right now, with other people. 3. Customers provide feedback in real time This phenomenon is happening now. Launch a product online and immediately you will you have five DMs in your inbox with suggestions or reports of bugs. The world becomes your test market, and iteration of your product happens in real time. 4. Conventions for real-time design are being defined now Real-time experience conventions are being created as new real-time services pop up all over the Web. It’s important to make note of what is working and what isn’t and imagine ways we can improve the experience. 5. Real-Time technologies need to be in your development plans As users come to expect information in real-time, real-time technologies need to be on your development and enhancement register. Discussion needs to happen now so we can understand how real-time might change your service delivery experience. The Summit is an UnconferenceBecause it’s an unconference, you’re going to get tons of networking and business value from the summit. Along with the help of a professional moderator, you and your peers will make the agenda and sit alongside industry luminaries such as John Borthwick, Chris Dixon and Marshall Kirkpatrick to discuss, debate and shape what comes next for the real-time Web. It’s like your own private think-tank. That’s the nature of ReadWriteWeb summits – straight-talking, collegial settings where you get to create the future. Everyone learns. Everyone advances. You leave feeling energized and full of “next”! Tags:#conferences#RWW Real-Time Web Summit, NYC 2010#web Why Tech Companies Need Simpler Terms of Servic… A Web Developer’s New Best Friend is the AI Wai…
Chelsea boss Lampard: My relationship with Giroud is really goodby Paul Vegas19 days agoSend to a friendShare the loveChelsea boss Frank Lampard says he speaks regularly with Olivier Giroud.The veteran has been on the outer this season.Lampard said, “My relationship with Olivier is really good. He’s a great professional, trains at a level every day, great in the dressing room and passes on his experience, but everyone keeps asking me about the players that aren’t playing. It’s a difficult one.”Some players can’t play, whether they’re 32 or at the other end of the spectrum at 21. They have to keep working and be positive within the group. I want the club to win and when I choose to select people or not, it’s because I think it’s the best thing.”Everyone wants to play, I understand that – I was one of the worst, I hated not playing – but all I want to see is positivity. I’m seeing that, and that’s something maybe the outside world doesn’t see. We need a big squad to be a successful team.” TagsTransfersAbout the authorPaul VegasShare the loveHave your say
Georgia doesn’t want to see a repeat of this in 2015.Louisville loses a number of defensive stars, including interception machine Gerod Holliman, from last year’s excellent defense, but a pair of Georgia transfers will look to pick up the slack. Josh Harvey-Clemons and Shaq Wiggins both played for current Louisville defensive coordinator at UGA. Harvey-Clemons was directly involved in Georgia’s heartbreaking 2013 loss to Auburn. Nick Marshall’s 4th-and-18 heave deflected off of his hands into those of receiver Ricardo Louis for the game-winning touchdown. That’s the type of play that could haunt a guy for his entire career, but for Harvey-Clemons, the chance to play Auburn again was a major selling point that helped lock up his transfer to Louisville.When former Georgia safety Josh Harvey-Clemons was being recruited to Louisville, one of the unexpected selling points for defensive coordinator Todd Grantham — formerly at UGA as well — was who the Cardinals would play in Harvey-Clemons’ first eligible game with the new program. Auburn. “When he said that,” Harvey-Clemons said, “I just knew it was meant for me to come here, really. I’ve been waiting to play them again. I look forward to it.”With Jeremy Johnson at quarterback, Auburn may be a bit more pass-oriented than they have been in recent years under Gus Malzahn. Harvey-Clemons and Wiggins might have a few opportunities to get some revenge on the Tigers come September 5 in Atlanta. [Courier-Journal]
BEIJING — Chinese telecom equipment giant Huawei has unveiled a processor chip for data centres and cloud computing in a bid to expand into an emerging global market despite Western warnings the company might be a security risk.Monday’s announcement comes as Chinese vendors that rely on Western technology step up efforts to develop their own.Huawei Technologies Ltd., the biggest global maker of network gear and the No. 2 smartphone brand, said its Kunpeng 920 chip is designed to process a growing flood of data from smartphones, entertainment and other services.The U.S., Australia and some other governments have labeled Huawei and other Chinese suppliers a security risk and imposed curbs on use of their technology. Huawei has denied accusations it is controlled by China’s ruling Communist Party or facilitates spying.The Associated Press
Madrid: Lionel Messi and Luis Suarez might have been rested but instead both played and scored as Barcelona came from behind to beat Rayo Vallecano, ahead of their crunch Champions League second leg against Lyon. Raul de Tomas’ scintillating strike gave struggling Rayo a surprise lead at the Camp Nou but Messi converted a penalty and Suarez finished a brilliant passing move to seal a 3-1 win, after Gerard Pique had headed in an equaliser on Saturday. Also Read – Dhoni, Paes spotted playing football togetherWhen Barca kicked off, Atletico Madrid had just completed their own 1-0 victory over Leganes, although Diego Simeone was more cautious, resting Antoine Griezmann, Alvaro Morata and Saul Niguez, with Tuesday’s trip to Juventus in mind. “It is normal when there is an important game on Tuesday,” said Simeone, who substituted Griezmann at half-time. “He was not injured, he had just given all that he had to give.” There was always a risk that La Liga’s top two might take their eye off the ball, given Barcelona’s last 16-tie with Lyon hangs in the balance after a goalless draw in France, while Atletico hold a 2-0 lead over Juve but can expect an onslaught in Turin. Also Read – Andy Murray to make Grand Slam return at Australian Open”We have a crucial match on Wednesday,” Ernesto Valverde said. “We know the importance it has for many reasons — because of the opponent, the competition and because we have seen what has happened to other big teams already.” Yet both avoided slip-ups to leave Real Madrid even further adrift in La Liga before they play away at Real Valladolid on Sunday. Barca stay seven points clear of Atletico and, temporarily at least, move 15 ahead of Real. Even with a two-goal cushion for the final eight minutes, Ernesto Valverde kept Messi and Suarez on until the end, which may have surprised some, given he was accused of exhausting key players last season at the expense of success in Europe. Messi’s appearance was his 443rd for Barcelona in La Liga, moving him ahead of Andres Iniesta and behind only Xavi Hernandez, on 505, in the club’s all-time list. Samuel Umtiti started his second match in three months after recovering from a knee injury. “Little by little he is reaching his level,” said Valverde. But Philippe Coutinho was underwhelming again, despite being picked ahead of Ousmane Dembele. He poked an early chance wide after a Messi cross and De Tomas put Rayo in front soon after, driving at Pique before unleashing a sizzling shot past Marc-Andre ter Stegen. Pique headed one Messi free-kick wide and then another in at the near post, nipping in front of Rayo goalkeeper Stole Dimitrievski to nod in his sixth goal of the season. Dembele came on for Arthur Melo at half-time and Coutinho dropped deeper, but it was right-back Nelson Semedo that earned the penalty, after a foul from Jordi Amat. Messi made no mistake. Rayo’s belief, and energy, melted away and Barca’s third was their best of the night. Suarez freed Dembele down the right and he found Suarez again with a pull-back. Instead of shooting, Suarez bounced the ball off Ivan Rakitic in the area before finally tapping home. There was nothing as free-flowing at the Wanda Metropolitano where perhaps the greatest show of creativity came from Leganes, whose players wore shirts with the name of their mothers on their backs to celebrate International Women’s Day on Friday. The first half was almost entirely forgettable but despite the absence of attacking punch, Griezmann came off at half-time for Thomas Lemar, with no visible sign of an injury. Griezmann would have taken the penalty soon after, won by Angel Correa with some quick feet in the area, which lured Kenneth Omeruo into a clumsy challenge. Saul stepped up and missed, but tucked in the rebound after Andriy Lunin could only push the ball back into his path.
New Delhi: A day after Jet Airways suspended all its flights after running out of money, lenders to the carrier Thursday said they were “reasonably hopeful” that bidding process for the airline will end successfully. Lenders led by the State Bank of India had declined to extend more funds to Jet, forcing it to suspend all its flights. “The lenders after due deliberations decided that the best way forward for the survival of Jet Airways is to get the binding bids from potential investors who have expressed EOI (Expression of Interest) and have been issued bid documents on April 16,” a statement by lenders said. Also Read – India gets first tranche of Swiss bank a/c details A consortium of 26 lenders led by the SBI, with 51 per cent stake in the debt-trapped airline, has invited bids from potential suitors. “Lenders are reasonably hopeful that the bid process is likely to be successful in determining the fair value of the enterprise in a transparent manner,” it said. Banks on Wednesday rejected an immediate Rs 400 crore demand of Jet Airways, compelling it to ground operations. Jet had been, over the last few months, on a decline as competition from budget airlines hurt its profitability and led to a debt pile. It reported losses for four straight quarters despite sales holding up. Also Read – Tourists to be allowed in J&K from Thursday At its peak, Jet operated 123 planes and over 600 daily flights. It was flying just seven planes on Tuesday. Its chief executive officer Vinay Dube on Wednesday wrote an email to airlines’ passengers saying “with deep sadness and with a heavy heart that we would like to share with you that, effective immediately, Jet Airways will be suspending all its domestic and international operations”. “Tuesday night, we were informed by SBI, on behalf of the consortium of Indian lenders, that they are unable to consider our request for interim funding. Since no emergency funding from the lenders or any other source of funding was forthcoming, it would therefore not have been possible for us to pay for fuel or other critical services to keep the operations going,” he wrote. He said the airline had over the last several weeks and months tried “every means possible” to seek funding, both interim as well as long term funding, to keep our operations going. “Unfortunately, despite the very best of our efforts, we have been left with no other choice today”. “A decision like this is never easy to make, but without the interim funding, which we have been repeatedly requesting for, we are simply unable to conduct flight operations in a manner that delivers to the very reasonable expectations of our guests, employees, partners and service providers,” he wrote. “After 25 years of sharing the Joy of Flying with Indian and international guests, Jet Airways and its Board of Directors have been forced to take this extreme measure, as prolonged and sustained efforts with lenders and authorities to ensure the sustainability of the airline did not yield the desired results.” He, however, said the future provides new hope and opportunity as India is better off with a flying Jet Airways. “We will now await the bid finalization process by SBI and the consortium of Indian lenders and will continue to support the bid process initiated by the lenders,” he added. Passengers who had booked on Jet for travel on future dates will get a refund. “We sincerely and profusely apologise for the disruption to your travel plans. We would like to thank you for your continued patronage, support and loyalty over the years. We are hopeful that we will be able to bring the Joy of Flying back to you soon,” he added.
A small crowd of enterprising dancers convened for the last performance of the festival event. [photo & text: Logan Bier] June 27, 2011The second day of the 13th annual Juneteenth Festival began with a lively performance by Shri, including members Lee Lozowick (vocals), Deborah Auletta (vocals), Doug Fulker (guitar & vocals), Franck Giambelluco (guitar), Nachama Greenwald (harmonica), Steve Ball (Hammond organ & electric piano), Tina Zuccarello (bass) and Zac Parker (drums). The band’s discography includes thirteen original albums, including their latest, Lucky Thirteen (2009). [photo: sue & text: Logan Bier] The crowd quickly grew more lively and energetic, making a wonderful finale for another very successful and fun weekend at Arcosanti.Many thanks to all of the residents, volunteers, performers and musicians that made this event possible![photo & text: Logan Bier] The Juneteenth festival drew to a close with a second, extended performance by Turner Jr. & Flavor, a reggae/funk band. [read more about this group at Daily Progress 2011/6/22 : /today/2011/06/22/1308759202172.html ]
State Rep. Jason Sheppard this week introduced legislation to increase the fines for drivers who text while driving.Sheppard’s plan increases the penalty for texting while driving in Michigan from $100 for a first violation to $250, and from $200 for a second violation up to $500.“When we get behind the wheel, we are responsible for our actions,” Sheppard said. “It’s my belief if drivers face higher fines for texting and driving, they may think twice before texting so they keep their focus where it should be – on the road.”Sheppard noted the recent case of a distracted driver involved in a crash on U.S. 23 in Monroe County, killing a mother and her daughter. The driver was charged with one count of reckless driving causing death.“Statistics are telling us that more people are not driving responsibly. If you’re the driver, set a good example by making the best choice for you and everyone on the road by putting the phone down and being responsible,” Sheppard said. “No text message is worth someone’s life.”The AAA Foundation for Traffic Safety found that drivers who text are up to eight times as likely to be involved in a crash.House Bill 4199 has been referred to the House Transportation Committee.### Categories: News,Sheppard News 15Feb Rep. Sheppard’s plan increases penalties for texting while driving
Letterkenny RoadNIXON’S CORNERPSNITRAFFIC & TRAVEL: ROAD IN DERRY CLOSED OVER FOUR VEHICLE COLLISION POLICE say the Letterkenny Road in Derry has been closed in both directions.It follows a road traffic collision involving four vehicles near Nixons Corner.Diversions are in place. ShareTweet Motorists are asked to avoid the area if possibleTRAFFIC & TRAVEL: ROAD IN DERRY CLOSED OVER FOUR VEHICLE COLLISION was last modified: November 16th, 2017 by John2John2 Tags:
Updated at 6:23 p.m. ETHundreds of students and faculty at two universities in Los Angeles have been asked to stay home unless they can prove that they’ve been vaccinated against measles.The LA campuses of the University of California and California State University imposed the quarantine after they became aware of people infected with measles who had potentially exposed hundreds. At UCLA, a student exposed at least 500 people earlier this month; at Cal State, someone with measles went to a library and encountered hundreds.California officials said Friday the two campuses have more than 650 students and staff under quarantine order.UCLA was notified by the LA County Department of Public Health that one of its students had contracted measles. After identifying people the infected student might have come in contact with while contagious, the school asked them to provide proof of immunization. On Wednesday, 119 people who couldn’t provide proof were quarantined.Of those, dozens were able to prove immunity and were released from quarantine by Thursday afternoon. But 82 were still quarantined, and “a few may need to remain in quarantine for up to seven days,” the school said in a statement.”Considering the time that has elapsed since the last possible exposure to the individual with measles on April 9, the highest risk period for developing measles has already passed — and the period during which symptoms may appear is nearing the end,” UCLA Chancellor Gene Block said.Los Angeles County declared Monday that the county was facing a measles outbreak, with international travel leading to five confirmed measles cases, including students from UCLA and Cal State L.A. So far this year, 38 people have been infected with measles in California, state officials said, according to the Los Angeles Times.As of Wednesday, the Centers for Disease Control and Prevention was reporting 695 cases of measles from 22 states — the highest it’s been since measles was ostensibly “eliminated” from the country in 2000. There’s been a 300% increase in the number of measles cases worldwide over the first three months of 2018, according to the World Health Organization. “That increase is part of a global trend seen over the past few years as other countries struggle with declining vaccination rates and may be exacerbating the situation here,” the CDC said. Copyright 2019 NPR. To see more, visit https://www.npr.org.
Oct 31 2018Following the 2018 Nobel Prize for Medicine, global attention is now more than ever turned toward the promise of immunotherapy in oncology. An international team’s work has shed new light on a molecule called TIM-3 that might play a key role in the regulation of the immune response. Scientists and physicians from the Research Institute of the McGill University Health Centre (RI-MUHC), the Montreal Children’s Hospital of the MUHC (MCH-MUHC), and McGill University in collaboration with French teams from AP-HP, Inserm, Université Paris-Descartes and the Imagine Institute at the Necker-Enfants Malades Hospital, have singled out this protein as the next potential target for immunotherapy treatments in patients with cancer and other diseases.These results are being published in the journal Nature Genetics on Monday, October 29.Researchers found that when the TIM-3 protein is suppressed or inactive, the immune system becomes completely “unleashed” and T cells are uncontrollably over-activated, resulting in a rare form of lymphoma (a form of cancer that starts in the lymphocytes) called subcutaneous panniculitis T lymphoma (LTSCP).The team of researchers has identified two founder mutations at the origin of this syndrome, which act directly on the TIM-3 protein, preventing it from expressing itself on the surface of the lymphocytes and attacking the cancer cells. They also found that this form of lymphoma associated with over-activation of the immune response was more widespread than they first thought. Both mutations have been found in individuals of East Asian, Australian, and Polynesian origin as well as in patients of European origin.This work was based on findings from the teams at the RI-MUHC and the MCH-MUHC, showing the same rare form of lymphoma in brother and sister. After sequencing their genomes, the researchers discovered that both patients carried the same mutation on a gene called HAVCR2 that codes for TIM-3 and that it was transmitted by their parents.In discussions with colleagues in Australia and France, the team realized they too had similar cases of patients with the same mutation (Tyr82Cys) who seemed to be mostly of East Asian or Polynesian descent. Another mutation (Ile97Met), on the same gene, was identified in patients of European origin. A functional study of these mutations, conducted in Paris, confirms their responsibility in this new genetic disease. In all, 17 pediatric and adult cases were the subject of this scientific publication.”The discovery of this mutation has shed light on a previously undescribed mechanism that allowed us to explain both the clinical presentation and the very particular evolution of these lymphomas under treatment,” explains Dr. David Michonneau from the hematology-transplant service in the Saint-Louis AP-HP hospital.Related StoriesLiving a healthy lifestyle may help offset genetic risk of dementiaGene modulation goes wireless hacking the “boss gene”Fungal infection study identifies specific genetic vulnerability among Hmong peopleAccording to Dr. Geneviève de Saint Basile from the laboratory “Molecular basis of immune homeostasis abnormalities” Inserm at the Imagine Institute and the center for the study of immunodeficiencies at Necker-Children’s Hospital AP-HP, “The results of this collaboration demonstrate the regulatory role of the TIM-3 molecule in humans and they also provide strong arguments for reconsidering this entity as an inflammatory rather than a malignant pathology, and for promoting the use of immunosuppressive drugs in its treatment.””For these patients with this rare form of lymphoma, our results reinforce the use of immunosuppressive therapies that will provide much better results and fewer side effects than cytotoxic chemotherapy,” says Dr. Nada Jabado, who is a clinician-scientist from the Child Health and Human Development Program at the RI-MUHC and a professor of Pediatrics and Human Genetics at McGill University in Montreal.Researchers are now trying to see if patients with autoimmune diseases such as lupus – a disease where the immune system turns against the body itself – may have some TIM-3 dysfunction. There would also be promising avenues for the treatment and understanding of cancers, infectious diseases such as HIV or even malaria as well as multiple sclerosis. Source:https://muhc.ca/newsroom/news/scientific-breakthrough-promising-new-target-immunotherapy
Reviewed by Kate Anderton, B.Sc. (Editor)Jan 25 2019The National Institutes of Health has awarded a R01 grant to a multi-institutional team to develop and evaluate a pregnancy-specific Artificial Pancreas in a sequence of in-clinic and transitional environment clinical trials. The researchers hope that the first-in-the-nation studies will lead to a safe and effective at-home clinical trial with an extension phase to the end of pregnancy.The project brings together the experienced engineering team of the Harvard John A. Paulson School of Engineering and Applied Sciences and a clinical research consortium made up of specialists from the Icahn School of Medicine at Mount Sinai, the Mayo Clinic, and the Sansum Diabetes Research Institute.”This work will bring our previous advancements in artificial pancreas technology to the next level, and will be the first project of its kind in the United States,” said Principal Investigator Dr. Eyal Dassau, Director of the Biomedical Systems Engineering Research Group at the Harvard John A. Paulson School of Engineering and Applied Sciences.”Achieving and maintaining the very narrow range blood glucose levels required for the best fetal outcomes for pregnant women with type 1 diabetes is extremely challenging, even with optimal clinical care,” said Carol J. Levy, MD, CDE, Clinical Director of the Mount Sinai Diabetes Center, who has managed the care of hundreds of pregnant women with this condition and serves as the project’s principal investigator at the Icahn School of Medicine at Mount Sinai. “The use of customized technology provides an important opportunity to improve patient and fetal outcomes. We are excited to be part of the team evaluating this important area of research designed to improve care and reduce patient burden.””Women with type 1 diabetes experience significant insulin reactions as they try to manage their glucose within a narrow target range throughout pregnancy. There has been no artificial pancreas trial involving pregnant women with type 1 diabetes in the U.S.,” states Yogish C. Kudva, Professor of Endocrinology at Mayo Clinic Rochester. “We are excited that we will adapting automated insulin delivery to relieve the burden on pregnant women with type 1 diabetes and their families.””This project will adapt the artificial pancreas to help pregnant women at each stage of pregnancy, progressing from a sequence of in-clinic studies to an outpatient trial,” said Dr. Jordan Pinsker, principal investigator of the project at Sansum Diabetes Research Institute (SDRI). “This project continues the legacy of the work of Dr. Lois Jovanovic, who performed her groundbreaking clinical trials at SDRI for 27 years, laying the foundation for the current standards of care in diabetes and pregnancy.”The first clinical trial in the grant, Longitudinal Observation of Insulin Requirements and Sensor Use in Pregnancy (LOIS-P), is named after Dr. Lois Jovanovic, and is now listed on clinicaltrials.gov (NCT03761615). This study is currently enrolling pregnant women with type 1 diabetes and will follow their glycemic outcomes throughout pregnancy and into the post-partum period.About the Research Consortium:Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS)Related StoriesStudy highlights need to consider patient’s weight before prescribing new cancer drugsSmall bioengineered implant promises long-lasting relief from Type 1 diabetesNew discovery may help predict recurrence of pancreatic neuroendocrine tumorsSEAS serves as the connector and integrator of Harvard’s teaching and research efforts in engineering, applied sciences, and technology. Through collaboration with researchers from all parts of Harvard, other universities, and corporate and foundation partners, we bring discovery and innovation directly to bear on improving human life and society. http://seas.harvard.edu.Icahn School of Medicine at Mount SinaiThe Type 1 Diabetes Research program at the Icahn School of Medicine at Mount Sinai focuses on clinical research projects specifically designed to improve the lives of patients with diabetes. There is a long history of both basic and clinical research in diabetes at Mount Sinai dating back to the discovery of the radioimmunoassay to measure serum insulin levels by Nobel Laureate Rosalyn Yalow, PHD in 1977. Researchers at Mount Sinai are running a robust outpatient artificial pancreas program in New York City. The goal for all diabetes research at Mount Sinai is to continue to develop new treatments and improve patient care until there is a cure.Mayo Clinic Rochester MNThe type 1 diabetes research program at Mayo Clinic Rochester is tightly integrated with the Diabetes Technology clinic which is a multi-disciplinary effort with dedicated Endocrinologists, Nurse Practitioners, CDEs and device technicians. The research program has conducted AP studies since 2013 and is currently conducting several AP studies working with academic engineering partners such as the Harvard School of Engineering AP program and industry partners. The Division of Endocrinology has been involved with Insulin related research since 1922 and also played a key role in early development of complex insulin therapy from 1975 to 1985.Sansum Diabetes Research InstituteMost recently, SDRI was the only US clinical site for the landmark CONCEPTT clinical trial, where 325 women who were either pregnant or planning pregnancy were randomized to continuous glucose monitoring use or fingerstick self-monitoring of blood glucose (SMBG) alone until delivery. Dr. Jovanovic, performed her groundbreaking work at SDRI for 27 years, from 1986-2013, laying the foundation for current standards for care in diabetes and pregnancy. Dr. Jovanovic was SDRI’s former Chief Executive Officer and Chief Scientific Officer from 1996-2013.”Dr. Jovanovic’s courageous and relentless fight to teach the world how to care for women with diabetes led to a global improvement in outcomes for both moms with diabetes and their babies,” said Dr. Kristin Castorino, also a co-investigator on the project at SDRI.”It is an honor for us at SDRI to continue Dr. Jovanovic’s legacy to improve the treatment of pregnant women with diabetes. Advancing her work in this field has always been part of SDRI’s commitment to both our community and the diabetes community at large to progress diabetes research and innovation for those impacted by type 1 diabetes, type 2 diabetes or gestational diabetes,” said Ellen Goodstein, SDRI’s Executive Director. Source:https://www.mountsinai.org/about/newsroom/2019/nih-funds-first-artificial-pancreas-study-in-the-united-states-for-pregnant-women
Jammu and Kashmir SHARE SHARE EMAIL Constitution mandates the concurrence of an elected State govt, says Abdullah state politics March 01, 2019 COMMENTS The National Conference (NC) and the People’s Democratic Party (PDP) said on Friday that they were mulling moving court against the Centre’s decision to extend the 77th and 103rd Amendments of the Constitution to Jammu and Kashmir in the absence of an elected government in the State.The reactions come after the Union government on Thursday gave its nod to the promulgation of an Ordinance for giving reservation benefits to the SCs and the STs in Jammu and Kashmir by amending a clause of the contentious Article 370, which gives special status to the State. “It will serve the purpose of application of relevant provisions of the Constitution , as amended through the Constitution (77th Amendment) Act, 1995, and Constitution (103rd Amendment) Act, 2019, for Jammu and Kashmir, by issuing the Constitution (Application to Jammu and Kashmir) Amendment Order, 2019, by the President under Clause (1) of Article 370,” Union Finance Minister Arun Jaitley had said.In a series of tweets, NC leader Omar Abdullah said, “Article 370 makes concurrence of Government of Jammu and Kashmir a condition precedent for extension of a Constitutional provision not falling under three subjects.”Abdullah said his party will consult eminent lawyers to explore how the decision can be challenged in the court of law.“The Government means an elected government. President cannot seek the concurrence of Governor who is a representative or agent of President. Same will apply even where only consent is required,” he tweeted.“It is for this reason that @JKNC_ will consult eminent lawyers tomorrow (Friday) to see how best we can challenge this blatantly unconstitutional order in court,” he added.‘Sinister move’PDP President Mehbooba Mufti said the Centre using the Governor’s office for extending the amendments to Jammu and Kashmir seemed to be a “sinister” move aimed at “disempowering” the State.“Ostensibly, using the Governor’s office seems to be a sinister move to further disempower the State. This will not be tolerated & the entire State will fight against this criminal and illegal move of GoI,” she said in a tweet.She questioned the intentions of the BJP-led NDA government at the Centre, asking why people of Kashmir were being pushed to the wall?Ban on Jamaat-e-IslamiMeanwhile, the PDP chief also condemned the Centre’s decision to ban the Jamaat-e-Islami Jammu and Kashmir, saying it was another example of “muscular approach” of the Centre to deal with the political issues of the State. “Democracy is a battle of ideas, crackdown followed by banning of Jammat Islami (JK) is condemnable, another example of high-handedness and muscular approach of GOI to deal with the political issue of J&K,”she tweeted. Published on COMMENT SHARE courts and legal
Floods affect 8 lakh in Assam, 10 dead across Northeast as rains lash region | 10 pointsHeavy rainfall and floods have affected the entire Eastern and Northeastern India. Over eight lakh people have been affected in Assam while the rain has disrupted life in north Bengal, Sikkim and other states.advertisement India Today Web Desk New DelhiJuly 12, 2019UPDATED: July 12, 2019 23:28 IST An village in Kamrup district of Assam on July 12. (Photo: IANS)Heavy rain and floods have thrown life out of gear in the entire eastern region with over eight lakh people being affected by the overflowing Brahmaputra in Assam. Non-stop rain in north Bengal and Sikkim has triggered several landslides, throwing normal life out of gear.Low-lying areas in north Bengal and Sikkim are also staring at a flood-like situation with the incessant rainfall while in Assam at least 6 people have been killed so far. A total of 10 people have died across three states of Assam, Arunachal Pradesh and Mizoram. Some are feared dead in Bengal.Here are the top 10 developments:1. Road connectivity between north Bengal and Sikkim has been completely disrupted by the continuous rainfall. Rail connectivity has also been disrupted in the Dooars region. Several tourists are struck on the road while two tourist vehicle were drawn into the Teesta River and bodies are yet to recovered due to the rising water levels in Teesta.2. Road connectivity between Siliguri and Sikkim has been shut. Heavy rain is expected till July 14.3. Over eight lakh people have been affected by the flood situation in Assam with more than half of the districts in the Northeastern state submerged under water.4. Barpeta in Assam is the worst hit district with over 85,000 people reeling under the impact of the floods. Six people have lost their lives in Assam so far.5. Animals are fleeing the Kaziranga National Park, the famed habitat of the Great Indian Rhino and a World Heritage site. Authorities have set up road barricades on the national highway passing through the park to limit speeding vehicles.6. The Assam disaster relief force has said nearly 800 villages in 41 revenue circles are under water and about2,000 marooned people have been put up in 53 relief camps and relief distribution centres set up by the district administrations.7. In Arunachal Pradesh, 2 girls were buried in their sleep and three others were injured after a landslide caused a boundary wall to collapse on the hostel building of a school in Tawang district.8. Arunachal capital Itanagar has been witnessing landslips, mudslides and road blockades due to heavy rainfall for several days and the district administration has ordered closure of all schools in Itanagar till Sunday.9. In Mizoram, 2 men have drowned and 390 houses submerged in floods triggered by incessant rain across the state. Disaster management and rehabilitation officials said landslides made many places inaccessible.10. The Itanagar-Naharlagun stretch of NH-415, which is being upgraded to a four-lane highway, is the worst hit by the monsoon fury.(With PTI inputs)Also Read | Incessant rains trigger landslides, bring life to a standstill in Arunachal PradeshAlso Watch | In Depth: Decoding the link between floods and droughtsFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted bySanchari Chatterjee Next
Parched Chennai gets relief as 1st train carrying 2.5 lakh litres of water reaches drought-stricken stateThe first water train, carrying 2.5 lakh litres of water in 50 wagons, departed from the Jolarpettai railway station at 7:20 am on Friday and reached Villivakam at 11:35 am. However, the train was first taken to Korukupet yard for maintenance.advertisement Lokpria Vasudevan ChennaiJuly 12, 2019UPDATED: July 12, 2019 17:33 IST Executed at the cost of Rs 65 crore, the train will make four trips every day to deliver nearly 10 million litres of water per day. (Photo: IANS)HIGHLIGHTSThe first water train reached Chennai on Friday to bring respite from water scarcity in the stateThe train is carrying 2.5 lakh litres of water in 50 wagonsThe train underwent maintenance and routine checks before water could be pumped outPeople in Chennai on Friday welcomed the water train which was promised to bring respite from water scarcity that the state has been facing for the past weeks. The train with number 23907 chugged into Villivakam railway station on Friday and was received with much fanfare and excitement.The first water train, carrying 2.5 lakh litres of water in 50 wagons, departed from the Jolarpettai railway station at 7:20 am and reached Villivakam at 11:35 am. However, the train was taken to Korukupet yard for maintenance.The train was later brought to Villivakam station at 2:30 pm when local bodies minister SP Velumani, Fisheries Minister D Jayakumar and other leaders were present at the station to receive the water train. According to officials, Chennai will be receiving drinking water by train after a gap of nearly 18 years. (Photo: IANS)Since the train was late, SP Velumani defended the delay in its arrival and said the train had to undergo maintenance and routine checks before water could be pumped out from the wagons.Executed at the cost of Rs 65 crore, the train will make four trips every day to deliver nearly 10 million litres of water per day.Fifty HP (horse power) capacity pumps have been installed at Villivakam station to complete unloading of water from the wagon in four hours. The decanted water will be carried in 600 metres of pipeline to the Kilpauk Water Works which is 3 km away. The water will be treated and distributed across the city.According to officials, Chennai will be receiving drinking water by train after a gap of nearly 18 years. Water was brought from Erode by trains in 2001 when the city faced a similar crisis.Tamil Nadu government zeroed in Vellore as the city is found to have a surplus of about 30 MLD of water.The Vellore Combined Drinking Water Supply Scheme which is fed by water from river Cauvery was launched in 2015. The first water train is carrying 2.5 lakh litres of water in 50 wagons. (Photo: IANS)On June 21, in a bid to address the severe water shortage in Chennai, Chief Minister Palaniswami announced that 10 MLD of drinking water would be transported from Vellore to Chennai for six months. The state government has allocated funds to the tune of Rs 65 crore to execute the plan.Also Read | Tamil Nadu CM announces water train to help parched ChennaiAlso Read | Water woes: Running out of time | India Today InsightAlso Watch | Is Chennai’s water emergency a man-made crisis?For the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byShifa Naseer Next