The Wyss Institute for Biologically Inspired Engineering at Harvard has been awarded a $12.3 million, four-year grant from the Defense Advanced Research Projects Agency (DARPA) to develop a treatment for sepsis, a commonly fatal bloodstream infection. Sepsis is a major cause of injury and death among combat-injured soldiers in the field, as well as patients in hospital intensive care units.The proposed treatment would involve a miniaturized, dialysislike device that could rapidly clear the blood of a wide range of pathogens, much as a living human spleen does, without removing normal blood cells, proteins, fluids, or electrolytes. This novel “Spleen-on-a-Chip” would be portable, self-contained, and easily inserted into the peripheral blood vessels of a septic patient or soldier.The award, which was announced Sept. 28, is part of DARPA’s Dialysis Like Therapeutics (DLT) program, which seeks to develop ways to dramatically decrease the morbidity and mortality of sepsis. Worldwide, more than 18 million cases of sepsis are reported every year, with more than 6 million resulting in death.“We are very proud to partner with DARPA to pursue a research effort that could potentially transform how we treat patients with sepsis and save lives by quickly cleansing blood free of pathogens while simultaneously treating with antibiotics,” says Donald Ingber, Wyss Institute founding director and principal investigator on the grant. “This is a tremendous example of how the Wyss Institute works to bring together outstanding faculty members, expert technical staff, interdisciplinary resources, novel technologies, and clinical partner institutions, such as Children’s Hospital Boston, to bear on critical medical problems.”The project also includes George Church, a Wyss core faculty member and professor of genetics at Harvard Medical School; Joanna Aizenberg, a Wyss core faculty member and Amy Smith Berylson Professor of Materials Science at the Harvard School of Engineering and Applied Sciences and Susan S. and Kenneth L. Wallach Professor at the Radcliffe Institute; and Michael Super, a member of the Wyss Advanced Technology Team, as key co-investigators.Researchers plan to incorporate several of the Wyss Institute’s novel technologies in the proposed sepsis dialysis device. The sepsis therapeutic device will leverage recent Wyss Institute advances in organ-on-chip technologies in which key microstructural features of complex organs, such as the spleen, are replicated in microfluidic circuits using microfabrication techniques.Also key to the technology is the use of magnetic nano- and micro-particles coated with a human opsonin — a key component of the body’s innate immune response — that will remove pathogens from flowing human blood using magnetic forces. The opsonin is being genetically engineered to improve its already broad pathogen-binding capacity using directed evolution strategies developed at the institute.In addition, the sepsis therapeutic device will incorporate a “super” slippery surface that was developed by institute researchers as a novel material to prevent the adhesion of ice, crude oil, or even dirt. This technology, which is modeled after the slippery surfaces of carnivorous plants that trap insects sliding into the digestive juices of the plant, will be modified to prevent blood clot formation so that patients will not need to be treated with anticoagulants, such as heparin, when attached to the sepsis therapeutic device.The Wyss Institute is a division of Harvard University. Operating in collaboration with Harvard Schools, Harvard-affiliated hospitals, Boston University, and the University of Massachusetts Medical School, the Wyss Institute conducts broad interdisciplinary research into the principles that living systems use to build, control, and manufacture, and applies these insights to develop novel materials and devices in areas as diverse as architecture, medicine, robotics, manufacturing, and the environment.
He is the eighth NHL coach to lose his job this season and the sixth fired for performance reasons. That matches the most for one season in NHL history, according to the Elias Sports Bureau.Assistant Dean Evason was named the Wild’s interim coach. Minnesota is 27-23-7 and three points out of a playoff position in the Western Conference with 25 games left to play.Boudreau was in his fourth season with the Wild. He previously coached the Washington Capitals and Anaheim Ducks.In other NHL news:— The St. Louis Blues say Jay Bouwmeester (BOH’-mees-tur) had surgery Friday to insert a defibrillator to restore his heart’s normal rhythm. The Blues defenseman collapsed on the bench during a game in Anaheim this week. Doctors quickly used a defibrillator to restore his heart beat and he regained consciousness before going to a hospital on Tuesday night. General manager Doug Armstrong says the procedure was performed at the UC Irvine Medical Center. Once Bouwmeester is cleared to return to St. Louis, he’ll be monitored by doctors at Barnes-Jewish Hospital and Washington University. February 14, 2020 Tickets will be priced at $224 each, two for $224 and $24.02 each — combinations of numbers that like the date, 2/24, represent the No. 24 worn by Bryant and the No. 2 worn by Gianna on her girls basketball team.Proceeds from the ticket sales will benefit the Mamba and Mambacita Sports Foundation, the Lakers said.Ticket registration was to extend from 11 a.m. Friday through 10 p.m. Monday through the Ticketmaster Verified Fan system. On Tuesday, registered fans will receive emails with non-transferable personal access codes that will allow them to participate in the public sale on Wednesday morning.In a move apparently intended to prevent a repeat of the massive crowds that flocked to Staples after Bryant’s death, the Lakers said the memorial will not be shown on exterior video screens at the arena or the adjacent L.A. Live entertainment area.LPGA-WOMEN’S AUSTRALIAN OPEN 7-time major champion Inbee Park tied for lead Down UnderADELAIDE, Australia (AP) — Seven-time major champion Inbee Park moved into contention for her 20th LPGA Tour victory on Friday by taking a share of the second-round lead at the Women’s Australian Open.Park shot 4-under 69 to put her at 10-under 136 at Royal Adelaide, tied with first-round leader Jodi Ewart Shadoff.Jillian Hollis, was in third place, one stroke behind. Defending champion Nelly Korda was six strokes behind. Five-time champion Karrie Webb, whose lead-up to the tournament was hampered by a virus, missed the cut after a second consecutive 74.Because of the virus outbreak in China, the Women’s Australian Open will be the last LPGA tournament for a month after the cancellation of three scheduled events in Thailand, Singapore and China. Coates was asked by a reporter if he was 100% confident that the Tokyo Olympics would go on as scheduled and open on July 24. He replied, “Yes.” Signed as a rookie free agent in 2014, Hurst played in all 16 regular-season games for the Ravens last season, with two starts at left tackle. He was part of an offensive line that paved the way for an NFL-record 3,296 yards rushing in 2019.The 28-year-old Hurst signed a four-year contract in March 2018. He didn’t miss a game over his first four seasons before being inactive for six games in 2018 with a back injury.KOBE BRYANT MEMORIALTicketing plan for Kobe Bryant public memorial releasedLOS ANGELES (AP) — The Los Angeles Lakers announced Friday that fans seeking to attend the Feb. 24 memorial for Kobe Bryant and his daughter, Gianna, at Staples Center must register to purchase tickets and there will be no outside overflow areas. In other MLB news:— All-Star closer Josh Hader lost his salary arbitration case against the Milwaukee Brewers, dropping players to 1-6 in hearings this year. Hader will earn $4.1 million rather than his $6.4 million request. Hader earned $687,600 last year. He had 37 saves in 44 chances and went 3-5 with a 2.62 ERA in his second straight All-Star season. He failed to hold a 3-1 lead in the eighth inning of the NL wild-card game. Seven players remain scheduled for hearings, which run through Feb. 21.— The Cleveland Indians are already dealing with adversity before taking the field for their first full-squad workout. Starting pitcher Mike Clevinger (KLEH’-vihn-jur) injured his left knee during a workout in Arizona and will have surgery. The team says he tore cartilage on Wednesday. A timetable for his return will be set after the operation. Clevinger won 13 games last season. The Indians are counting on him to have a larger role after two-time Cy Young winner Corey Kluber was traded this winter— The Atlanta Braves have signed first baseman Yonder Alonso to a minor league contract with an invitation to the major league spring training. The 32-year-old Alonso gives the Braves depth behind Freddie Freeman, who had surgery in October on his right elbow. Freeman said last month he has no pain in the elbow and will be ready when position players report on Monday.— Washington Nationals general Mike Rizzo is not satisfied with the way the Houston Astros attempted to apologize for their sign-stealing scandal. Rizzo’s Nationals beat the Astros in last season’s World Series and were prepared in case Houston tried any funny stuff. Rizzo said people from other teams in baseball reached out to the Nationals to offer advice before they faced the Astros in the Fall Classic. Rizzo said the Astros cheated to win the 2017 World Series and he would like to hear members of Houston’s organization use the word “cheated” to describe what they did. MLB-SALARY RAISE-MINOR LEAGUERSAP Exclusive: MLB raises salaries for minor leaguers in 2021NEW YORK (AP) — Major League Baseball is raising the minimum salary for minor league players in 2021, according to a memo sent Friday from the commissioner’s office to all 30 teams and obtained by The Associated Press.Two years after successfully lobbying Congress to exempt minor leaguers from federal minimum wage laws, MLB opted to give those players a wage increase between 38% and 72%. The bump was discussed at last week’s owners meetings and confirmed in the memo from Morgan Sword, executive vice president of baseball economics and operations.Players at rookie and short-season levels will see their minimum weekly pay raised from $290 to $400, and players at Class A will go from $290 to $500. Double-A will jump from $350 to $600, and Triple-A from $502 to $700. Update on the latest sports Minor leaguers are paid only during the five-month season and don’t receive wages during the offseason or spring training.NFL-RAVENS-HURST SUSPENDEDRavens OL James Hurst suspended 4 games for PED useOWINGS MILLS, Md. (AP) — Baltimore Ravens offensive lineman James Hurst has been suspended for the first four games of the 2020 season for violating the NFL policy on performance enhancers.Hurst is eligible to participate in all preseason practices and games. He will be allowed to return to his team’s active roster on the Monday following the team’s fourth game. TOKYO OLYMPICS-VIRUSNo ‘Plan B’ for Olympics; questions over Chinese presenceTOKYO (AP) — Tokyo Olympic organizers and the International Olympic Committee said Friday there is no “Plan B” for the 2020 Games, which open in just over five months and have been jolted by the outbreak of a virus in neighboring China.The coronavirus has infected almost 64,000 people globally with almost 1,400 deaths in China, but only one in Japan, where fear is rising with so much attention focused on the outbreak.John Coates, the head of an IOC inspection team, and Tokyo Olympic organizers took questions at a news conference on Friday to wrap up a two-day visit that was dominated by the virus issue. Share This StoryFacebookTwitteremailPrintLinkedinRedditNHL-NEWSMinnesota fires BoudreauUNDATED (AP) — The Minnesota Wild have fired coach Bruce Boudreau. — The Buffalo Sabres have placed defenseman Zach Bogosian on waivers. The move comes months after Bogosian asked to be traded and opens a spot on Buffalo’s blue line for young players like Lawrence Pilut. Bogosian has five points in 19 games this season. The 29-year-old has been in and out of the lineup with hip injuries. Bogosian is in the final year of his contract and counts $5.14 million against the salary cap. He would be assigned to Rochester of the American Hockey League if he clears waivers. Bogosian has 53 goals and 141 assists in 636 regular-season games with the Atlanta Thrashers, Winnipeg Jets and Sabres.MLB-NEWSHaniger has second surgeryUNDATED (AP) — Seattle Mariners outfielder Mitch Haniger isn’t likely to take the field anytime soon following his second surgery in less than a month. The Mariners say the 2018 All-Star had a lower back procedure Thursday that followed core surgery in January.Both are related to a ruptured testicle sustained in a game last June, an injury believed to have occurred when he fouled off a pitch and the ball hit him in the groin area. In working his way back, Haniger felt back pain and never played again last season. Associated Press
Tiger Woods conceded he was running out of time to win major titles after falling out of contention at the PGA Championship on Saturday.The 44-year-old American shot a 2-over 72 for a second successive round, which left him with little to play for leading into the final day at TPC Harding Park in San Francisco. TIGER ON SUNDAY: How to watch his round at the PGAThe tournament will represent another opportunity missed for the reigning Masters champion in his bid to equal Jack Nicklaus’ record of 18 major victories. Woods has managed 15 over a 24-year professional career, but only one since 2008.”There’s not as many [opportunities to win] as when I first started playing,” Woods said after completing his round. “The reality is that the golf courses are getting bigger. They are getting longer. The margin between making the cut and the lead is a lot smaller than it used to be. Used to be sometimes 12 to 15 shots.”Now we had, what, nine shots here? It’s just different. It’s getting tighter and it’s getting harder to win events, but you look at the leaderboard of most major championships, you see the same guys.2 birdies.4 bogeys.4 fairways hit.12 greens in regulation.31 putts.Tiger Woods cards a 2-over 72 in Round 3 of the PGA Championship. He’s +2 for the tournament. pic.twitter.com/cG7XCaJfUH— PGA TOUR (@PGATOUR) August 8, 2020“May not be always the same winners, but you see the same handful of guys are there. They understand how to win major championships, how to win the big events, how to plod their way along, how difficult it is to win these big events.”Putting again proved a problem for Woods as he failed to make a birdie until the 16th hole. Though well behind the contenders, Woods said he had a clear goal in mind for the final round.”You just keep fighting, no matter what,” he said. “Whether the rounds are shooting 61s or shooting 81s, the intensity should always be there, the effort should always be there. I keep fighting until the end [with] pride in what I do. I love to compete. Unfortunately I didn’t do my job today.”At the end it clicked and hopefully I can get something going tomorrow and get into the red for the tournament.”