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CDC releases viruses for novel H1N1 vaccine development

first_imgMay 27, 2009 (CIDRAP News) – Sanofi Pasteur announced today that it has received a novel H1N1 influenza vaccine virus from the Centers for Disease Control and Prevention (CDC), moving the company a step closer to starting production of a vaccine.CDC spokesman Tom Skinner said this afternoon that the agency is also sending the vaccine virus to other manufacturers, located overseas, who should receive the samples within a few days.Jeff McLaughlin, a spokesman for vaccine maker GlaxoSmithKline (GSK), said today he couldn’t confirm GSK’s receipt of the vaccine strain, but added, “We understand that the CDC is in the process of shipping the strain to all the relevant manufacturers.”CDC and World Health Organization (WHO) officials had predicted that the CDC would release H1N1 vaccine viruses to manufacturers by the end of May. WHO officials have said that production of H1N1 vaccines is most likely to begin in July.The preparation of a vaccine strain involves combining a clinical sample of the target virus with another influenza virus that grows in eggs. This process creates a new virus that has some of the properties of the target virus and the ability to grow in eggs, the US Department of Health and Human Services noted today in a fact sheet on vaccine development activities. Most flu vaccines are still produced by growing them in eggs.Wayne Pisano, president of Sanofi Pasteur, said in a news release, “As a company committed to protecting human health, Sanofi Pasteur looks forward to quickly understanding how this virus performs in a vaccine manufacturing environment and developing a working seed that will enable large-scale production.”Sanofi will now begin “passaging” the virus, referring to “the process for acclimating virus to grow in a production environment at optimum yield,” the company said. The process will take about 2 weeks.”Following quality controls, Sanofi Pasteur will be prepared to begin industrial production as soon as directed by public health agencies,” the statement added.Health officials have estimated it would take manufacturers 4 to 6 months from when they receive the vaccine strain to start producing a vaccine in quantity. But a Sanofi spokeswoman said last week that the company may be able to start producing its first doses in 3 to 4 months.Sanofi and GSK both announced within the past few days that they had received US government orders for novel H1N1 vaccines.In related news, the WHO has recommended that vaccines for the novel H1N1 influenza virus be based on an isolate from California, saying most H1N1 viruses isolated so far are very similar to it.A majority of the novel H1N1 viruses isolated so far are antigenically and genetically related to the isolate known as A/California/7/2009 (H1N1), the WHO said in a statement posted online yesterday.The WHO said that its collaborating laboratories, certain regulatory agency laboratories, and other partners are developing reassortant viruses antigenically similar to the California strain for use in vaccines.Skinner, of the CDC, said the agency used the California strain in making the vaccine virus now being released to manufacturers.WHO spokesman Gregory Hartl said several other WHO collaborating centers and regulatory laboratories are developing novel H1N1 vaccine viruses. He said they include St. Jude Children’s Research Hospital in Memphis, a US Food and Drug Administration lab, and facilities in Japan, the United Kingdom, and Australia.See also: May 27 Sanofi press releaseMay 26 CIDRAP News story “Companies receive HHS orders for novel flu vaccine”WHO recommendation on strain for vaccine developmentlast_img read more

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Cal Poly looks to sweep CSUN

first_img Share This StoryFacebookTwitteremailPrintLinkedinRedditCal Poly (7-16, 4-5) vs. Cal State Northridge (10-15, 5-4)Matadome, Northridge, California; Thursday, 10 p.m. ESTBOTTOM LINE: Cal State Northridge seeks revenge on Cal Poly after dropping the first matchup in San Luis Obispo. The teams last played each other on Jan. 11, when the Mustangs shot 52.7 percent from the field while limiting Cal State Northridge’s shooters to just 35.8 percent en route to a 74-56 victory. Cal Poly looks to sweep CSUN BIG MEN ON CAMPUS: Cal State Northridge’s Lamine Diane has averaged 22.3 points and 8.9 rebounds while Terrell Gomez has put up 20.2 points. For the Mustangs, Junior Ballard has averaged 13 points while Tuukka Jaakkola has put up 7.9 points.CLAMPING DOWN: The Matadors have given up only 72 points per game across nine conference games, an improvement from the 84.1 per game they gave up in non-conference play.JUMPING FOR JUNIOR: Ballard has connected on 37.1 percent of the 89 3-pointers he’s attempted and has made 11 of 25 over the last five games. He’s also made 73.6 percent of his free throws this season.WINLESS WHEN: Cal Poly is 0-14 when scoring fewer than 69 points and 7-2 when scoring at least 69.UNBEATEN WHEN: Cal Poly is a perfect 6-0 when it scores at least 74 points. The Mustangs are 1-16 when scoring any fewer than 74.DID YOU KNOW: Cal State Northridge is rated first among Big West teams with an average of 74.5 points per game. Associated Press center_img February 12, 2020 ___For more AP college basketball coverage: https://apnews.com/Collegebasketball and http://twitter.com/AP_Top25___This was generated by Automated Insights, http://www.automatedinsights.com/ap, using data from STATS LLC, https://www.stats.comlast_img read more

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Suns have begun interviewing GM candidates, report says

first_img WATCH: Stephen Curry tosses alley-oop to Parkland student Ryan McDonough, the general manager coming into the season for the Suns, was fired Oct. 8 before the first game of the year. Since then, James Jones and Trevor Bukstein have served as the team’s co-interim general managers. Related News They are expected to stay with the team in some capacity.Phoenix is an NBA-worst 12-50 on the season and just recently broke a 17-game losing streak. The Suns are ready to find their next general manager.Phoenix has begun the process of interviewing candidates for the job, according to 98.7 FM Arizona’s Sports Station.last_img read more

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Iowa National Guard’s top general announces retirement

first_imgJOHNSTON, Iowa (AP) — The adjutant general of the Iowa National Guard has announced his plans for retirement.A National Guard news release says Maj. Gen. Tim Orr intends to step down effective May 1 after 10 years as the Iowa Guard’s commander. He was named to the post by then Gov. Chet Culver in March 2009.Brig. Gen. Stephen Osborn will serve as the interim adjutant general.Orr enlisted in the Iowa Army National Guard in 1978 while still a senior at Boone High School and rose through the ranks.last_img read more

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