On Thursday, Lacson claimed that severalCabinet officials have apprehensions and reservations about Duterte’s move toscrap the 1998 military deal and were worried about the possible repercussionsof the abrogation. “Basically, that’s the message. I mean,consistent naman si Pangulo diyan eh. We will pursue an independent foreignpolicy where we are friends to everyone and enemies to none. And I think whenthe President gave that statement, I think all he’s saying is that hindi tayopwede mag side sa kahit sino,” he added. “All members of the Cabinet support thePresident’s foreign policy,” Panelo said. The VFA, which was signed in February1998, allows the entry of US troops sans passport and visa regulations so theycan participate in joint military drills in the Philippines./PN Cabinet Secretary Karlo Nograles,for his part, said that Lacson’s statement was mere “speculation.” Presidential Spokesperson Salvador Paneloissued this statement to dispute the claim of Senator Panfilo Lacson thatDuterte’s revocation of VFA was not fully backed by all Cabinet members. Presidential Spokesperson Salvador Panelo says all members of the Cabinet support President Rodrigo Duterte’s foreign policy, contrary to the claim of Sen. Panfilo Lacson. ABS-CBN NEWS “Let me assure, everybody, that when thePresident makes a decision, all, the entire Cabinet will support him there. Andthat includes VFA,” Nograles said. MANILA – Theentire Cabinet supports President Rodrigo Duterte’s move interminating the Visiting Forces Agreement (VFA) between the Philippines andUnited States, Malacañang said.
Jul 11 2018Osaka University scientists clarify how E.coli bacteria attach to human intestinesOsaka University-led researchers clarified how pathogenic E. coli bacteria attached to the host intestinal epithelium. They revealed that type IV pili on the surface of the bacteria were not sufficient for adherence to intestinal epithelial cells and that proteins secreted by E.coli were also necessary. It was found that this attachment mechanism might be a common feature in many enteropathogens such as Vibrio cholera and constitutes a novel therapeutic target against such bacterial pathogens.Enterotoxigenic Escherichia coli (ETEC) is known as a major cause of diarrhea in travelers and people living in developing countries. According to the World Health Organization (WHO), ETEC is responsible for 300,000 ~ 500,000 deaths a year, constituting a serious problem.Effective vaccines for ETEC have not been developed, so patients infected with ETEC are treated with antibiotics and supporting measures. However, the emergence of multidrug-resistant bacteria has become a social issue, so the development of new treatment methods is sought after.Adherence to the host intestinal epithelium is an essential step for ETEC infection in humans. It was thought that a filamentous structure on the surface of bacteria called ‘type IV pilus’ was important for bacterial attachment, but its detailed adhesion mechanism was not known.Osaka University-led researchers clarified how pathogenic E.coli attached to the host intestinal epithelium using type IV pili and secreted proteins. Their research results were published in PNAS.Related StoriesStructure of bacteria responsible for traveler’s diarrhea decipheredMother calls for protein shake regulation after daughter diesNew protein target for deadly ovarian cancerOne of the corresponding authors, Shota Nakamura, says, “We demonstrated that type IV pili on the surface of the bacteria were not sufficient for ETEC adherence to intestinal epithelial cells and that proteins secreted by E.coli were also necessary. The administration of antibodies against the secreted proteins inhibited attachment of the E.coli.”Using X-ray crystallography, the researchers studied how a protein located only at the pilus-tip interacts with a protein secreted by E.coli in the intestines (Figure 2), clarifying the attachment mechanism of ETEC; that is, secreted proteins serve as molecular bridges that bind both type IV pili on the surface of the bacteria and intestinal epithelial cells in humans.Nakamura also says, “It’s possible that this attachment is a common feature in many type IV pili expressing enteropathogens such as Vibrio cholerae and constitutes a new therapeutic target against such bacterial pathogens.”Their research results will lead to the development of not only new vaccines for ETEC, but also anti-adhesion agents for preventing the binding of proteins implicated in bacterial attachment. Anti-adhesion agents can rinse pathogenic bacteria out from the body without destroying them, so there is no danger of producing drug-resistant bacteria. These agents, once developed, will act as a novel treatment approach that may serve as an alternative to antibiotics. Source:http://resou.osaka-u.ac.jp/en/research/2018/20180629_3